TMEM205

Across TCGA pan-cancer cohorts, TMEM205 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM205’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM205 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM205 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where TMEM205 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM205 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.581	<.001	11	view →
COAD	Female	All	+0.892	<.001	10	view →
KICH	Female	II,III,IV	−1.495	<.001	9	view →
LIHC	All	II,III,IV	+0.567	<.001	7	view →
BRCA	All	III,IV	+0.770	<.001	6	view →
STAD	All	II,III,IV	+0.415	.002	6	view →
THCA	Male	II,III,IV	−0.483	.004	5	view →
KIRP	Male	II,III,IV	+0.619	.001	4	view →
LUSC	All	III,IV	−0.523	<.001	4	view →
UCEC	All	All	+0.491	.019	2	view →
CHOL	Female	All	+1.016	.025	1	view →
ESCA	All	All	+0.682	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM205–KIRC

Open the KIRC breakdown →