TMEM200A

Across TCGA patient cohorts, TMEM200A mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM200A-associated genes across cancer lineages are p38-MAPK_pT180_Y182, ASNS, and p27_pT198. Each is linked with TMEM200A in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM200A-to-partner and partner-to-TMEM200A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by TMEM200A-low versus TMEM200A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM200A→partner) and Y-score (partner→TMEM200A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p38-MAPK_pT180_Y182 →	-0.322	-3.169	.012	.018	3	4
COAD	ASNS →	+0.473	+3.008	.021	.019	3	4
LUAD	p27_pT198 →	+0.145	+2.338	.002	.017	3	3
LUSC	p38-MAPK →	-0.169	-3.450	.007	.005	3	3
LUSC	Caveolin-1 →	-0.742	-2.312	.010	.035	3	3
UCEC	Cyclin-B1 →	+0.587	+2.321	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

p38-MAPK_pT180_Y182 by TMEM200A expression — LUAD

Explore this box plot interactively →