TMEM200A

Across TCGA pan-cancer cohorts, TMEM200A RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TMEM200A data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM200A RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM200A expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, STAD, and BLCA are the cancer types where TMEM200A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.726	0.532	<.001	146	view →
STAD	OS	Median	III,IV	0.198	0.501	.001	100	view →
BLCA	DFS	Quartile	All	0.565	0.732	.002	65	view →
UCS	DFS	Median	III,IV	0.460	0.125	.004	64	view →
MESO	OS	Median	III,IV	0.274	0.488	.001	56	view →
ACC	DFS	Median	All	0.192	0.675	<.001	56	view →
UVM	DFS	Quartile	II,III,IV	0.392	0.763	.005	41	view →
SKCM	OS	Quartile	II,III,IV	0.940	0.732	.003	40	view →
KIRP	OS	Quartile	II,III,IV	0.760	0.149	<.001	33	view →
LAML	DFS	Quartile	All	0.251	0.662	<.001	30	view →
SCLC	OS	Tertile	IV	0.137	0.556	.025	18	view →
THCA	DFS	Median	II,III,IV	0.869	0.468	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TMEM200A–KIRC (OS)

Open the KIRC breakdown →