TMEM200A

Across TCGA pan-cancer cohorts, TMEM200A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM200A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TMEM200A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM200A is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where TMEM200A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM200A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+2.159	<.001	12	view →
HNSC	All	IV	+1.140	<.001	12	view →
KICH	Female	All	−2.412	<.001	8	view →
UCEC	All	All	−2.498	<.001	6	view →
LIHC	All	All	+0.313	<.001	6	view →
STAD	All	II,III,IV	+1.217	.001	4	view →
BRCA	All	II,III,IV	+0.414	<.001	4	view →
CHOL	All	All	+1.430	<.001	3	view →
KIRP	All	All	+1.094	.001	3	view →
READ	Female	All	−1.976	.010	2	view →
LUSC	Female	All	−0.692	.011	2	view →
LUAD	All	All	+0.512	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM200A–KIRC

Open the KIRC breakdown →