Across TCGA patient cohorts, TMEM186 protein abundance is significantly associated with the RNA expression of many other genes, with 5,121 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM186-associated genes across cancer lineages are PALM2AKAP2, ARSB, and HLX. Each is linked with TMEM186 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM186-to-partner and partner-to-TMEM186 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM186→partner) and Y-score (partner→TMEM186) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PALM2AKAP2 →	-1.037	-0.648	<.001	.006	3	3
OV	ARSB →	-0.833	-0.606	<.001	<.001	3	3
HNSC	HLX →	-0.474	-0.670	.003	.004	3	3
GBM	SRPX →	-1.603	-0.377	<.001	.001	3	3
OV	PIK3CG →	-0.876	-0.653	<.001	<.001	3	3
GBM	ITGA4 →	-0.982	-0.403	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,121 associations by consensus.

Exploration

TMEM186 survival (RNA) · tumor vs normal (RNA) · all TMEM186 data types