TMEM183A

Across TCGA patient cohorts, TMEM183A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM183A-associated genes across cancer lineages are Ku80, Notch1, and STAT3_pY705. Each is linked with TMEM183A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM183A-to-partner and partner-to-TMEM183A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TMEM183A-low versus TMEM183A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM183A→partner) and Y-score (partner→TMEM183A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.260	+2.183	.035	.035	3	1
UCEC	Notch1 →	+0.196	+2.817	.008	.036	3	1
UCEC	STAT3_pY705 →	-0.519	-3.169	<.001	.018	3	1
UCEC	TFRC →	+0.872	+2.999	.001	.035	3	1
UCEC	Beclin →	+0.100	+3.321	.043	.010	3	1
UCEC	Caspase-8 →	-0.304	-2.973	.021	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Ku80 by TMEM183A expression — UCEC

Explore this box plot interactively →