TMEM18-DT

Across TCGA patient cohorts, TMEM18-DT RNA expression is significantly associated with the go_rna of many other GO terms, with 6,934 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible TMEM18-DT-associated GO terms across cancer lineages are Positive regulation of chromosome organization, Peptidyl-lysine modification, and Protein polyubiquitination. Each is linked with TMEM18-DT in more than 27 cancer types. Because this analysis shows association rather than direction, both TMEM18-DT-to-partner and partner-to-TMEM18-DT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome organization grouped by TMEM18-DT-low versus TMEM18-DT-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM18-DT→partner) and Y-score (partner→TMEM18-DT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of chromosome organization →	+0.048	+0.159	<.001	<.001	3	28
STAD	Peptidyl-lysine modification →	+0.042	+0.138	<.001	<.001	3	28
ESCA	Protein polyubiquitination →	+0.052	+0.111	.003	<.001	3	28
STAD	Protein stabilization →	+0.043	+0.123	<.001	<.001	3	27
THYM	Centrosome duplication →	+0.059	+0.294	<.001	<.001	3	27
ESCA	Regulation of microtubule cytoskeleton organization →	+0.039	+0.095	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,934 associations by consensus.

Positive regulation of chromosome organization by TMEM18-DT expression — STAD

Explore this box plot interactively →