TMEM18-DT

Across TCGA pan-cancer cohorts, TMEM18-DT RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TMEM18-DT data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher TMEM18-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM18-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

UCS, UVM, and READ are the cancer types where TMEM18-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	II,III,IV	0.576	0.148	.001	60	view →
UVM	DFS	Tertile	All	0.494	1.000	.001	57	view →
READ	OS	Median	II,III,IV	1.000	0.299	<.001	44	view →
LGG	DFS	Tertile	All	0.665	0.834	<.001	43	view →
LIHC	DFS	Quartile	All	0.421	0.624	<.001	42	view →
KIRP	DFS	Median	All	0.469	0.702	.005	33	view →
SKCM	OS	Median	IV	0.867	0.236	.003	24	view →
LUAD	DFS	Tertile	IV	1.000	0.220	.017	22	view →
OV	OS	Quartile	III,IV	0.850	0.786	.021	20	view →
CESC	DFS	Quartile	II,III,IV	0.555	0.904	.002	20	view →
ACC	OS	Tertile	II,III,IV	0.731	0.993	.005	19	view →
BLCA	DFS	Tertile	All	0.466	0.680	.020	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TMEM18-DT–UCS (DFS)

Open the UCS breakdown →