TMEM18-DT

Across TCGA pan-cancer cohorts, TMEM18-DT RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TMEM18-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM18-DT RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM18-DT is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, BLCA, and KIRP are the cancer types where TMEM18-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM18-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.204	<.001	6	view →
BLCA	All	All	+0.127	.010	6	view →
KIRP	Male	All	−0.126	<.001	3	view →
UCEC	All	All	−0.390	.001	2	view →
CHOL	All	All	+0.198	.002	2	view →
LUSC	All	All	+0.103	.002	2	view →
ESCA	All	II,III,IV	+0.100	.009	2	view →
KIRC	Male	All	−0.073	.009	2	view →
LIHC	Male	All	+0.031	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TMEM18-DT–KICH

Open the KICH breakdown →