TMEM178B

Across TCGA patient cohorts, TMEM178B mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM178B-associated genes across cancer lineages are DAZ3, FAM47B, and CXorf66. Each is linked with TMEM178B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM178B-to-partner and partner-to-TMEM178B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ3 grouped by TMEM178B-low versus TMEM178B-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM178B→partner) and Y-score (partner→TMEM178B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	DAZ3 →	+0.034	+5.189	<.001	.006	3	1
SCLC	FAM47B →	+0.043	+4.847	.008	.009	3	1
SCLC	CXorf66 →	+0.224	+5.624	<.001	.003	3	1
SCLC	TSPY8 →	+2.882	+5.189	<.001	.006	3	1
SCLC	TSPY4 →	+2.503	+5.624	<.001	.003	3	1
CESC	RPL5P10 →	+0.048	+4.269	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

DAZ3 by TMEM178B expression — SCLC

Explore this box plot interactively →