TMEM178B

Across TCGA pan-cancer cohorts, TMEM178B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMEM178B data layer compared with 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TMEM178B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM178B expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

UVM, PAAD, and UCEC are the cancer types where TMEM178B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.419	0.742	<.001	106	view →
PAAD	OS	Quartile	All	0.678	0.386	<.001	53	view →
UCEC	OS	Tertile	All	0.883	0.950	.003	46	view →
SKCM	OS	Quartile	All	0.371	0.219	.005	32	view →
THYM	DFS	Quartile	All	0.610	1.000	.005	28	view →
LUAD	OS	Quartile	II,III,IV	0.880	0.634	.002	14	view →
COAD	DFS	Tertile	II,III,IV	0.688	0.851	.020	12	view →
SCLC	DFS	Quartile	II,III,IV	0.584	0.272	.012	10	view →
MESO	OS	Median	II,III,IV	0.341	0.705	.021	9	view →
ACC	DFS	Tertile	IV	0.679	0.126	.024	9	view →
PRAD	DFS	Tertile	All	0.940	0.879	.034	6	view →
HNSC	DFS	Median	IV	0.419	0.312	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMEM178B–UVM (DFS)

Open the UVM breakdown →