TMEM174

Across TCGA cell cohorts, TMEM174 RNA expression is significantly associated with the mutation status of many other genes, with 79 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TMEM174-associated genes across cancer lineages are BRCA2, TCF20, and CNTRL. Each is linked with TMEM174 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM174-to-partner and partner-to-TMEM174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRCA2 grouped by TMEM174-low versus TMEM174-high in BLOOD_Lymphoma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM174→partner) and Y-score (partner→TMEM174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BRCA2 →	+2.321	+0.162	.008	.001	3	3
LUNG_SCLC	TCF20 →	+3.523	+0.076	.008	<.001	3	2
BREAST	CNTRL →	+3.087	+0.010	.002	<.001	3	2
BREAST	CD109 →	+4.672	+0.014	.002	<.001	3	2
BREAST	KCNH4 →	+4.087	+0.014	<.001	<.001	3	2
PANCREAS	EPHB2 →	+3.554	+0.263	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

BRCA2 by TMEM174 expression — BLOOD_Lymphoma

Explore this box plot interactively →