TMEM174

Across TCGA pan-cancer cohorts, TMEM174 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated TMEM174 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TMEM174 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM174 expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

UCEC, KIRP, and KIRC are the cancer types where TMEM174 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.649	0.888	<.001	144	view →
KIRP	OS	Tertile	II,III,IV	0.694	0.306	<.001	138	view →
KIRC	OS	Median	All	0.698	0.558	<.001	136	view →
KICH	DFS	Tertile	III,IV	1.000	0.059	<.001	89	view →
THCA	OS	Quartile	All	0.942	0.993	.001	29	view →
THYM	DFS	Median	II,III,IV	0.948	0.762	.004	27	view →
CHOL	DFS	Tertile	All	0.037	0.486	.001	18	view →
ACC	DFS	Tertile	IV	0.656	0.113	.013	18	view →
LGG	DFS	Quartile	All	0.750	0.890	.003	8	view →
GBM	DFS	Median	All	0.190	0.292	.019	6	view →
LUAD	OS	Tertile	All	0.787	0.319	.025	6	view →
SKCM	DFS	Tertile	II,III,IV	0.486	0.697	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

TMEM174–UCEC (OS)

Open the UCEC breakdown →