TMEM171

Across TCGA cell cohorts, TMEM171 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM171-associated genes across cancer lineages are OR2J3, USP17L13, and USP17L17. Each is linked with TMEM171 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM171-to-partner and partner-to-TMEM171 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2J3 grouped by TMEM171-low versus TMEM171-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM171→partner) and Y-score (partner→TMEM171) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2J3 →	+0.017	+3.938	.004	.005	3	1
OVARY	USP17L13 →	+0.008	+4.222	<.001	.006	3	1
OVARY	USP17L17 →	+0.008	+4.222	<.001	.006	3	1
LARGE_INTESTINE	COX6A2 →	+0.136	+6.022	<.001	.001	3	1
LARGE_INTESTINE	BEND2 →	+0.032	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CCER1 →	+0.019	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2J3 by TMEM171 expression — OVARY

Explore this box plot interactively →