TMEM171

Across TCGA pan-cancer cohorts, TMEM171 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM171’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMEM171 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM171 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LUAD are the cancer types where TMEM171 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM171 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−3.165	<.001	11	view →
COAD	Female	All	−2.121	<.001	11	view →
LUAD	Female	II,III,IV	+1.809	<.001	9	view →
LUSC	Male	All	+2.148	<.001	6	view →
HNSC	All	All	+0.721	.003	6	view →
KICH	All	All	−1.475	<.001	5	view →
LIHC	All	All	+0.598	.003	4	view →
BRCA	Female	All	+0.439	<.001	4	view →
CHOL	All	All	+2.332	<.001	3	view →
READ	All	All	−1.674	<.001	2	view →
PRAD	All	All	−0.397	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM171–THCA

Open the THCA breakdown →