TMEM169

Across TCGA patient cohorts, TMEM169 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,631 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM169-associated proteins across cancer lineages are PPFIBP1, COL1A1, and COL5A2. Each is linked with TMEM169 in more than 6 cancer types. Because this analysis shows association rather than direction, both TMEM169-to-partner and partner-to-TMEM169 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM169 versus PPFIBP1 in LSCC, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM169→partner) and Y-score (partner→TMEM169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPFIBP1 →	+0.386	+0.283	<.001	<.001	3	7
COAD	COL1A1 →	+0.731	+0.284	.001	<.001	3	7
LSCC	COL5A2 →	+0.725	+0.312	<.001	<.001	3	7
LSCC	MRC2 →	+0.568	+0.396	.001	<.001	3	7
PDAC	ZNF532 →	+0.821	+0.581	<.001	<.001	3	6
BRCA	CNN2 →	+0.503	+0.270	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,631 associations by consensus.

TMEM169 vs PPFIBP1 — LSCC

Explore this scatter interactively →