TMEM169

Across TCGA pan-cancer cohorts, TMEM169 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TMEM169 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TMEM169 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM169 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

STAD, UCEC, and KIRC are the cancer types where TMEM169 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Quartile	II,III,IV	0.273	0.555	.001	77	view →
UCEC	DFS	Tertile	All	0.527	0.790	<.001	64	view →
KIRC	DFS	Quartile	All	0.934	0.775	.003	62	view →
HNSC	DFS	Quartile	III,IV	0.719	0.449	<.001	49	view →
LGG	DFS	Tertile	All	0.464	0.286	<.001	34	view →
SCLC	DFS	Median	II,III,IV	0.503	0.231	.006	30	view →
ACC	OS	Tertile	All	0.696	1.000	.006	30	view →
UVM	DFS	Tertile	All	0.383	0.805	.010	22	view →
ESCA	DFS	Median	II,III,IV	0.506	0.259	.001	20	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	18	view →
DLBC	DFS	Median	All	0.607	0.922	.005	14	view →
KICH	DFS	Tertile	II,III,IV	0.507	1.000	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TMEM169–STAD (DFS)

Open the STAD breakdown →