TMEM161B

Across TCGA cell cohorts, TMEM161B mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM161B-associated genes across cancer lineages are CFHR2, SERTM2, and CCKAR. Each is linked with TMEM161B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM161B-to-partner and partner-to-TMEM161B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by TMEM161B-low versus TMEM161B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM161B→partner) and Y-score (partner→TMEM161B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	2
CNS	SERTM2 →	+0.364	+3.358	<.001	.009	3	2
OESOPHAGUS	CCKAR →	+0.059	+4.017	<.001	.007	3	1
LARGE_INTESTINE	MAS1 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GPR171 →	+0.014	+3.103	.001	.004	3	1
LARGE_INTESTINE	FAM205C →	+0.008	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CFHR2 by TMEM161B expression — LARGE_INTESTINE

Explore this box plot interactively →