TMEM151B

Across TCGA patient cohorts, TMEM151B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM151B-associated genes across cancer lineages are AMPK_pT172, eEF2, and eIF4E. Each is linked with TMEM151B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM151B-to-partner and partner-to-TMEM151B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_pT172 grouped by TMEM151B-low versus TMEM151B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM151B→partner) and Y-score (partner→TMEM151B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AMPK_pT172 →	+0.524	+3.169	.011	.019	3	2
UCEC	eEF2 →	+0.461	+2.321	.010	.035	3	1
UCEC	eIF4E →	+0.264	+3.169	.012	.019	3	1
UCEC	ERK2 →	+0.225	+2.321	.020	.035	3	1
UCEC	Heregulin →	-0.203	-3.321	.001	.010	3	1
UCEC	N-Ras →	-0.165	-3.150	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

AMPK_pT172 by TMEM151B expression — UCEC

Explore this box plot interactively →