TMEM151B

Across TCGA pan-cancer cohorts, TMEM151B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM151B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM151B RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM151B is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where TMEM151B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM151B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.641	<.001	11	view →
LIHC	Female	All	+0.027	<.001	8	view →
KIRC	Male	II,III,IV	−0.069	<.001	7	view →
BRCA	Female	All	−0.156	<.001	6	view →
READ	All	All	−0.640	<.001	5	view →
LUSC	All	All	+0.470	<.001	5	view →
THCA	All	All	−0.049	.001	5	view →
HNSC	Male	II,III,IV	+0.258	.012	4	view →
STAD	All	All	−0.231	.021	2	view →
CHOL	All	All	+0.132	.001	2	view →
PRAD	All	All	−0.105	.004	2	view →
KIRP	Male	II,III,IV	−0.053	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM151B–COAD

Open the COAD breakdown →