TMEM151B

Across TCGA pan-cancer cohorts, TMEM151B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TMEM151B data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TMEM151B RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM151B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

HNSC, KIRC, and LGG are the cancer types where TMEM151B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.433	0.247	<.001	126	view →
KIRC	OS	Quartile	All	0.500	0.711	<.001	77	view →
LGG	DFS	Median	All	0.501	0.281	<.001	54	view →
PAAD	OS	Median	All	0.486	0.278	.002	44	view →
STAD	DFS	Median	III,IV	0.380	0.600	.007	33	view →
SCLC	DFS	Quartile	II,III,IV	0.628	0.229	.010	25	view →
BRCA	OS	Tertile	All	0.638	0.518	.003	21	view →
COAD	DFS	Quartile	II,III,IV	0.661	0.864	.003	21	view →
UCEC	DFS	Tertile	IV	0.844	0.497	.018	16	view →
THCA	OS	Tertile	All	0.977	0.994	.008	15	view →
THYM	DFS	Tertile	All	0.811	0.987	.003	15	view →
UVM	OS	Median	II,III,IV	0.878	0.534	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TMEM151B–HNSC (OS)

Open the HNSC breakdown →