TMEM151B

Across TCGA cell cohorts, TMEM151B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,345 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM151B-associated GO terms across cancer lineages are Heterochromatin formation, Negative regulation of gene expression, epigenetic, and Regulation of DNA recombination. Each is linked with TMEM151B in more than 15 cancer types. Because this analysis shows association rather than direction, both TMEM151B-to-partner and partner-to-TMEM151B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by TMEM151B-low versus TMEM151B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM151B→partner) and Y-score (partner→TMEM151B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Heterochromatin formation →	+0.058	+0.200	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.059	+1.493	<.001	.004	2	16
BONE	Regulation of DNA recombination →	+0.108	+1.485	<.001	.001	3	14
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.075	+0.483	.005	.006	2	15
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.088	+0.158	<.001	<.001	3	14
BONE	Heterochromatin organization →	+0.070	+1.321	.008	.005	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,345 associations by consensus.

Heterochromatin formation by TMEM151B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →