TMEM151B

Across TCGA cell cohorts, TMEM151B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM151B-associated genes across cancer lineages are PITX3, RSPH4A, and MYH8. Each is linked with TMEM151B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM151B-to-partner and partner-to-TMEM151B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PITX3 grouped by TMEM151B-low versus TMEM151B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM151B→partner) and Y-score (partner→TMEM151B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PITX3 →	+0.180	+3.374	<.001	.005	3	1
LARGE_INTESTINE	RSPH4A →	+0.213	+3.259	.006	.006	3	1
LARGE_INTESTINE	MYH8 →	+0.060	+2.657	.005	.007	3	1
LARGE_INTESTINE	MS4A3 →	+0.079	+3.285	.001	.007	3	1
LARGE_INTESTINE	FCN2 →	+0.025	+3.678	<.001	.001	3	1
LARGE_INTESTINE	SPEM2 →	+0.045	+2.989	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PITX3 by TMEM151B expression — LARGE_INTESTINE

Explore this box plot interactively →