TMEM151B

Across TCGA cell cohorts, TMEM151B mutation is significantly associated with the mutation status of many other genes, with 2,231 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM151B-associated genes across cancer lineages are CARD10, POP1, and RBM28. Each is linked with TMEM151B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM151B-to-partner and partner-to-TMEM151B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARD10 grouped by TMEM151B-low versus TMEM151B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM151B→partner) and Y-score (partner→TMEM151B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CARD10 →	+2.321	+2.919	.003	.003	1	2
LARGE_INTESTINE	POP1 →	+2.415	+3.510	<.001	<.001	1	2
LARGE_INTESTINE	RBM28 →	+2.678	+2.807	.006	.006	1	2
LARGE_INTESTINE	PHC1 →	+2.321	+2.919	.003	.003	1	2
LARGE_INTESTINE	BTNL8 →	+4.584	+3.350	.003	.003	1	2
LARGE_INTESTINE	GPS2 →	+4.584	+3.350	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,231 associations by consensus.

CARD10 by TMEM151B expression — LARGE_INTESTINE

Explore this box plot interactively →