TMEM14C

Across TCGA patient cohorts, TMEM14C mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM14C-associated genes across cancer lineages are C20orf181, RNU6-1020P, and RNA5SP421. Each is linked with TMEM14C in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM14C-to-partner and partner-to-TMEM14C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf181 grouped by TMEM14C-low versus TMEM14C-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM14C→partner) and Y-score (partner→TMEM14C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	C20orf181 →	+0.206	+5.038	<.001	.009	3	2
UCEC	RNU6-1020P →	+0.465	+4.005	<.001	.002	3	2
UCEC	RNA5SP421 →	+1.270	+3.018	<.001	.009	3	2
UCEC	MIR3155A →	+0.507	+3.884	<.001	.003	3	1
COAD	LINC01707 →	+0.291	+5.693	<.001	.003	3	1
COAD	RPL9P15 →	+0.269	+5.080	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

C20orf181 by TMEM14C expression — LUSC

Explore this box plot interactively →