TMEM14C

Across TCGA pan-cancer cohorts, TMEM14C RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TMEM14C data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TMEM14C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM14C expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

ACC, LIHC, and SARC are the cancer types where TMEM14C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.228	0.681	<.001	68	view →
LIHC	OS	Median	All	0.609	0.765	<.001	68	view →
SARC	OS	Tertile	All	0.409	0.769	.002	25	view →
LUAD	DFS	Median	IV	0.816	0.298	.019	24	view →
ESCA	DFS	Median	III,IV	0.311	0.553	.006	24	view →
UVM	DFS	Quartile	III,IV	0.191	1.000	.006	21	view →
HNSC	DFS	Median	All	0.444	0.638	.010	20	view →
BRCA	DFS	Median	All	0.925	0.879	.005	19	view →
KICH	OS	Quartile	II,III,IV	0.479	1.000	.004	18	view →
THCA	DFS	Median	All	0.880	0.779	.007	11	view →
THYM	DFS	Quartile	All	1.000	0.848	.018	11	view →
CESC	OS	Tertile	IV	0.408	0.771	.028	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TMEM14C–ACC (DFS)

Open the ACC breakdown →