TMEM14C

Across TCGA pan-cancer cohorts, TMEM14C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM14C’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where TMEM14C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM14C is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

LIHC, KICH, and KIRC are the cancer types where TMEM14C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM14C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.315	<.001	9	view →
KICH	Female	II,III,IV	−1.778	<.001	8	view →
KIRC	All	All	+0.238	<.001	7	view →
KIRP	All	II,III,IV	+0.440	.002	6	view →
HNSC	All	III,IV	+0.383	.001	6	view →
CHOL	Male	All	+1.656	<.001	5	view →
STAD	All	II,III,IV	+0.349	.013	3	view →
PRAD	All	All	−0.470	<.001	2	view →
UCEC	All	All	−0.381	.015	2	view →
LUSC	All	III,IV	−0.750	.040	1	view →
LUAD	Male	All	+0.319	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TMEM14C–LIHC

Open the LIHC breakdown →