TMEM147-AS1

Across TCGA pan-cancer cohorts, TMEM147-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TMEM147-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM147-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM147-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

KIRC, UCS, and ACC are the cancer types where TMEM147-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.465	0.699	<.001	115	view →
UCS	OS	Tertile	II,III,IV	0.666	0.185	<.001	96	view →
ACC	DFS	Median	All	0.366	0.795	<.001	83	view →
READ	OS	Tertile	II,III,IV	0.766	0.444	.001	51	view →
LGG	DFS	Median	All	0.619	0.840	<.001	43	view →
BLCA	OS	Tertile	All	0.779	0.645	.002	33	view →
HNSC	DFS	Quartile	IV	0.785	0.560	.001	32	view →
PRAD	DFS	Median	All	0.828	0.935	<.001	26	view →
COAD	OS	Quartile	All	0.689	0.884	.004	24	view →
BRCA	OS	Tertile	III,IV	0.969	0.840	.001	22	view →
UCEC	DFS	Median	All	0.799	0.876	.006	18	view →
SKCM	OS	Quartile	IV	1.000	0.233	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TMEM147-AS1–KIRC (DFS)

Open the KIRC breakdown →