Q-omics provides the consensus-scored TMEM147-AS1 profile across patient tissues and cancer cell-line models. TMEM147-AS1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, TMEM147-AS1 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, TMEM147-AS1 RNA expression shows 19,623 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, COAD, and ACC as cancer lineages where TMEM147-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM147-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM147-AS1 survival associations across molecular data types. TMEM147-AS1 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM147-AS1 RNA expression–survival associations across cancer types. High TMEM147-AS1 expression shows unfavorable associations in KIRC, ACC and LGG, but favorable associations in UCS, READ and BLCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for TMEM147-AS1 RNA expression.
This table summarizes TMEM147-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for TMEM147-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM147-AS1 shows lower tumor expression in KIRC and higher tumor expression in COAD, LIHC, BLCA, HNSC and CHOL. The COAD box plot shows higher TMEM147-AS1 RNA expression in tumor versus normal tissue (log2 FC = +1.888, t-test p < 0.001).
This table shows molecular features associated with TMEM147-AS1 in patient tissues and cancer cell lines. In patient samples, TMEM147-AS1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, TMEM147-AS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in NCI60_ALL.
