TMEM147-AS1

Across TCGA pan-cancer cohorts, TMEM147-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM147-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM147-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM147-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, LIHC, and BLCA are the cancer types where TMEM147-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM147-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.888	<.001	12	view →
LIHC	Female	II,III,IV	+0.781	<.001	9	view →
BLCA	All	III,IV	+1.175	<.001	8	view →
HNSC	Male	III,IV	+0.554	<.001	8	view →
KIRC	All	II,III,IV	−0.326	<.001	7	view →
CHOL	All	All	+1.958	<.001	5	view →
READ	Female	All	+1.556	<.001	5	view →
LUSC	Male	II,III,IV	+1.056	<.001	5	view →
STAD	All	II,III,IV	+0.586	.001	4	view →
KICH	All	All	−0.375	.021	3	view →
UCEC	All	III,IV	+0.779	.021	2	view →
ESCA	Female	All	+0.566	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM147-AS1–COAD

Open the COAD breakdown →