TMEM134

Across TCGA patient cohorts, TMEM134 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM134-associated genes across cancer lineages are RNU4-35P, RNY4P3, and RNU6-728P. Each is linked with TMEM134 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM134-to-partner and partner-to-TMEM134 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-35P grouped by TMEM134-low versus TMEM134-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM134→partner) and Y-score (partner→TMEM134) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-35P →	+0.402	+3.453	<.001	.009	3	1
UCEC	RNY4P3 →	+0.595	+4.418	<.001	<.001	3	1
UCEC	RNU6-728P →	+0.294	+4.335	<.001	.007	3	1
UCEC	MIR550A1 →	+0.442	+3.599	.008	.007	3	1
UCEC	RNU6-628P →	+0.627	+3.888	<.001	.002	3	1
UCEC	RNA5SP146 →	+0.377	+3.525	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RNU4-35P by TMEM134 expression — UCEC

Explore this box plot interactively →