TMEM132E

Across TCGA patient cohorts, TMEM132E mutation is significantly associated with the RNA expression of many other genes, with 4,874 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM132E-associated genes across cancer lineages are SKA1, POLE2, and PLBD1-AS1. Each is linked with TMEM132E in more than 3 cancer types. Because this analysis shows association rather than direction, both TMEM132E-to-partner and partner-to-TMEM132E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by TMEM132E-low versus TMEM132E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132E→partner) and Y-score (partner→TMEM132E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.741	+1.635	<.001	<.001	3	4
UCEC	POLE2 →	+0.355	+1.343	.003	.001	3	4
COAD	PLBD1-AS1 →	-0.647	-2.295	.001	.006	3	4
UCEC	BUB3 →	+0.390	+2.338	<.001	<.001	3	3
UCEC	GMEB1 →	+0.269	+1.624	.001	<.001	3	3
UCEC	ALPL →	-1.165	-1.469	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,874 associations by consensus.

SKA1 by TMEM132E expression — UCEC

Explore this box plot interactively →