TMEM132E

Across TCGA pan-cancer cohorts, TMEM132E RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TMEM132E’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM132E RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM132E is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

KICH, LUAD, and LIHC are the cancer types where TMEM132E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM132E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−2.062	<.001	9	view →
LUAD	Female	All	+0.409	<.001	8	view →
LIHC	Male	All	−0.467	<.001	6	view →
BRCA	Female	All	+0.255	.004	6	view →
THCA	Female	All	+0.232	.007	3	view →
PRAD	All	All	−0.224	.020	2	view →
KIRP	Male	All	−0.884	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TMEM132E–KICH

Open the KICH breakdown →