TMEM132A

Across TCGA cell cohorts, TMEM132A mutation is significantly associated with the mutation status of many other genes, with 5,333 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM132A-associated genes across cancer lineages are BRPF3, ARID2, and ZNF644. Each is linked with TMEM132A in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM132A-to-partner and partner-to-TMEM132A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRPF3 grouped by TMEM132A-low versus TMEM132A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM132A→partner) and Y-score (partner→TMEM132A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRPF3 →	+4.614	+2.637	<.001	<.001	1	6
BLOOD_Leukemia	ARID2 →	+3.845	+3.548	.003	.003	1	5
SOFT_TISSUE	ZNF644 →	+5.502	+5.502	.003	.003	1	5
BLOOD_Lymphoma	DOCK6 →	+2.969	+3.337	.009	.009	1	5
BLOOD_Lymphoma	FAM83H →	+3.232	+3.523	.006	.006	1	5
LARGE_INTESTINE	CAND1 →	+2.655	+2.413	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,333 associations by consensus.

BRPF3 by TMEM132A expression — LARGE_INTESTINE

Explore this box plot interactively →