TMEM132A

Across TCGA pan-cancer cohorts, TMEM132A RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM132A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM132A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM132A is over-expressed in tumor.

COAD, HNSC, and BLCA are the cancer types where TMEM132A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM132A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+2.502	<.001	12	view →
HNSC	Female	III,IV	+2.440	<.001	12	view →
BLCA	Male	III,IV	+3.214	<.001	11	view →
LUAD	Male	III,IV	+2.069	<.001	11	view →
KIRC	Male	IV	+1.463	<.001	11	view →
STAD	Male	II,III,IV	+1.852	<.001	9	view →
LIHC	Female	All	+1.542	<.001	9	view →
LUSC	Female	II,III,IV	+3.161	<.001	8	view →
THCA	Female	III,IV	+1.575	<.001	8	view →
KIRP	All	All	+0.987	.001	8	view →
READ	All	All	+1.938	<.001	7	view →
UCEC	All	II,III,IV	+3.384	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM132A–COAD

Open the COAD breakdown →