TMEM131

Across TCGA patient cohorts, TMEM131 protein abundance is significantly associated with the RNA expression of many other genes, with 11,917 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM131-associated genes across cancer lineages are PLCL1, HPGDS, and MTURN. Each is linked with TMEM131 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM131-to-partner and partner-to-TMEM131 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM131 versus PLCL1 in GBM, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM131→partner) and Y-score (partner→TMEM131) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCL1 →	-0.896	-0.210	<.001	<.001	3	4
LUAD	HPGDS →	-0.581	-0.163	.005	.002	3	4
GBM	MTURN →	-1.406	-0.281	<.001	<.001	3	4
UCEC	SLC8A1 →	-0.660	-0.242	.003	.009	3	4
CCRCC	FAT4 →	-0.794	-0.241	<.001	<.001	3	4
PDAC	EPS15 →	-0.373	-0.371	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,917 associations by consensus.

TMEM131 vs PLCL1 — GBM

Explore this scatter interactively →