TMEM131

Across TCGA pan-cancer cohorts, TMEM131 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM131 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TMEM131 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM131 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

MESO, ACC, and KIRC are the cancer types where TMEM131 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.257	0.577	<.001	114	view →
ACC	DFS	Tertile	All	0.273	0.827	<.001	82	view →
KIRC	DFS	Median	All	0.769	0.498	<.001	62	view →
LGG	OS	Median	All	0.746	0.880	<.001	51	view →
LIHC	DFS	Tertile	All	0.433	0.595	.001	43	view →
HNSC	DFS	Tertile	III,IV	0.463	0.278	.007	33	view →
KIRP	OS	Median	II,III,IV	0.527	0.926	.011	24	view →
STAD	DFS	Tertile	IV	0.150	0.597	.009	23	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
PRAD	DFS	Tertile	All	0.955	0.859	.001	18	view →
UVM	DFS	Quartile	All	0.277	0.774	.006	16	view →
UCEC	DFS	Median	IV	0.625	0.302	.030	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM131–MESO (OS)

Open the MESO breakdown →