TMEM131

Across TCGA pan-cancer cohorts, TMEM131 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM131’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM131 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM131 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where TMEM131 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM131 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.070	<.001	10	view →
HNSC	All	III,IV	+0.659	<.001	10	view →
LIHC	Female	II,III,IV	+1.166	<.001	8	view →
LUSC	All	All	+0.586	<.001	6	view →
LUAD	All	All	+0.364	.001	6	view →
BRCA	All	II,III,IV	+0.230	<.001	6	view →
CHOL	All	All	+1.612	<.001	5	view →
KICH	Female	All	−0.963	<.001	5	view →
STAD	Male	II,III,IV	+0.700	.008	5	view →
KIRP	All	II,III,IV	+0.504	.009	4	view →
PAAD	Male	All	+0.610	.017	2	view →
READ	All	All	−0.481	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM131–COAD

Open the COAD breakdown →