TMEM131

Across TCGA cell cohorts, TMEM131 mutation is significantly associated with the RNA expression of many other genes, with 691 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM131-associated genes across cancer lineages are ACTL7A, ZFAND4, and FOXR1. Each is linked with TMEM131 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM131-to-partner and partner-to-TMEM131 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTL7A grouped by TMEM131-low versus TMEM131-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM131→partner) and Y-score (partner→TMEM131) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ACTL7A →	+0.041	+4.044	<.001	.005	3	3
LARGE_INTESTINE	ZFAND4 →	+0.805	+3.502	.002	.001	3	3
BONE	FOXR1 →	+3.034	+3.584	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	FBXO47 →	+0.016	+4.044	.005	.001	3	2
UPPER_AERODIGESTIVE_TRACT	PVALEF →	+0.067	+3.862	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	SPEM3 →	+0.030	+4.451	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 691 associations by consensus.

ACTL7A by TMEM131 expression — OESOPHAGUS

Explore this box plot interactively →