TMEM125

Across TCGA cell cohorts, TMEM125 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM125-associated genes across cancer lineages are GHRH, PTH2R, and CFAP47. Each is linked with TMEM125 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM125-to-partner and partner-to-TMEM125 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by TMEM125-low versus TMEM125-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM125→partner) and Y-score (partner→TMEM125) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GHRH →	+0.296	+5.196	<.001	.005	3	1
LARGE_INTESTINE	PTH2R →	+1.548	+3.453	<.001	.009	3	1
LARGE_INTESTINE	CFAP47 →	+0.199	+3.453	.007	.009	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CLPSL1 →	+0.140	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GHRH by TMEM125 expression — OVARY

Explore this box plot interactively →