TMEM125

Across TCGA pan-cancer cohorts, TMEM125 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TMEM125’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEM125 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM125 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where TMEM125 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM125 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−1.287	<.001	12	view →
KICH	Male	II,III,IV	−3.223	<.001	11	view →
KIRC	Male	II,III,IV	−1.309	<.001	11	view →
LUSC	Female	II,III,IV	−4.278	<.001	9	view →
KIRP	All	III,IV	−2.636	<.001	9	view →
LUAD	Male	III,IV	−2.221	<.001	9	view →
THCA	Male	III,IV	−0.637	<.001	8	view →
BRCA	All	III,IV	+1.414	<.001	6	view →
BLCA	All	All	+1.359	.018	6	view →
READ	All	II,III,IV	−0.790	.017	5	view →
CHOL	Male	All	+4.566	<.001	4	view →
UCEC	All	All	+2.347	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TMEM125–HNSC

Open the HNSC breakdown →