TMEM121B

Across TCGA patient cohorts, TMEM121B mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM121B-associated genes across cancer lineages are RN7SL714P, FAM47B, and CXorf66. Each is linked with TMEM121B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM121B-to-partner and partner-to-TMEM121B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL714P grouped by TMEM121B-low versus TMEM121B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121B→partner) and Y-score (partner→TMEM121B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL714P →	+0.091	+3.115	.009	.007	3	2
SCLC	FAM47B →	+0.043	+4.847	.008	.009	3	1
SCLC	CXorf66 →	+0.224	+5.624	<.001	.003	3	1
SCLC	NEBL →	+0.657	+5.189	<.001	.006	3	1
HNSC	MIR449B →	+0.323	+7.954	<.001	.008	3	1
CESC	UBE2Q2P10 →	+0.055	+5.010	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

RN7SL714P by TMEM121B expression — UCEC

Explore this box plot interactively →