TMEM121B

Across TCGA pan-cancer cohorts, TMEM121B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TMEM121B data layer compared with 3 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher TMEM121B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM121B expression acts as an unfavorable survival marker, although some lineages such as STAD and HNSC show a favorable association.

STAD, HNSC, and LGG are the cancer types where TMEM121B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	II,III,IV	0.599	0.330	<.001	90	view →
HNSC	DFS	Quartile	III,IV	0.786	0.553	<.001	54	view →
LGG	OS	Median	All	0.545	0.309	<.001	48	view →
UVM	DFS	Tertile	II,III,IV	0.292	0.670	.007	47	view →
LIHC	OS	Median	III,IV	0.201	0.513	<.001	44	view →
COAD	OS	Tertile	II,III,IV	0.424	0.825	.001	41	view →
PAAD	DFS	Tertile	All	0.470	0.290	.002	38	view →
CHOL	DFS	Tertile	All	0.673	0.217	.006	34	view →
OV	OS	Tertile	III,IV	0.808	0.871	.002	26	view →
SKCM	DFS	Median	IV	0.639	0.064	.002	24	view →
LAML	DFS	Tertile	All	0.835	0.407	<.001	24	view →
LUSC	DFS	Tertile	III,IV	0.466	1.000	.010	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

TMEM121B–STAD (DFS)

Open the STAD breakdown →