TMEM121B

Across TCGA cell cohorts, TMEM121B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TMEM121B-associated genes across cancer lineages are PRSS54, OR10A4, and C14orf180. Each is linked with TMEM121B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM121B-to-partner and partner-to-TMEM121B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by TMEM121B-low versus TMEM121B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121B→partner) and Y-score (partner→TMEM121B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.038	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR10A4 →	+0.048	+3.938	.006	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.102	+3.155	.002	.008	3	1
LUNG_SCLC	DDI1 →	+0.052	+3.847	<.001	.005	3	1
LUNG_SCLC	SMIM9 →	+0.050	+3.817	<.001	.004	3	1
LUNG_SCLC	CCL23 →	+0.146	+4.614	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PRSS54 by TMEM121B expression — LARGE_INTESTINE

Explore this box plot interactively →