TMED10

Across TCGA patient cohorts, TMED10 mutation is significantly associated with the RNA expression of many other genes, with 3,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED10-associated genes across cancer lineages are FAM204DP, RNU6-6P, and BTBD10. Each is linked with TMED10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED10-to-partner and partner-to-TMED10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM204DP grouped by TMED10-low versus TMED10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED10→partner) and Y-score (partner→TMED10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM204DP →	+0.161	+3.993	.001	.005	3	2
COAD	RNU6-6P →	+1.006	+3.877	<.001	.008	3	2
UCEC	BTBD10 →	+0.609	+3.732	<.001	<.001	3	1
UCEC	LIN7C →	+0.687	+3.850	<.001	<.001	3	1
UCEC	PGAP2 →	+0.422	+3.922	.002	<.001	3	1
UCEC	HSD17B12 →	+0.540	+3.480	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,357 associations by consensus.

FAM204DP by TMED10 expression — COAD

Explore this box plot interactively →