TMED10

Across TCGA pan-cancer cohorts, TMED10 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMED10’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMED10 RNA is repressed in tumor relative to normal tissue. In most cancer types TMED10 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and BLCA are the cancer types where TMED10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMED10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.994	<.001	10	view →
HNSC	Female	All	+0.886	<.001	10	view →
BLCA	All	III,IV	+0.539	.001	9	view →
LIHC	All	II,III,IV	+0.551	<.001	8	view →
LUSC	Female	All	+0.436	<.001	5	view →
LUAD	Male	All	+0.356	<.001	5	view →
CHOL	Male	All	+1.311	<.001	4	view →
KICH	All	All	−0.535	.001	4	view →
STAD	All	All	+0.340	.004	4	view →
BRCA	All	II,III,IV	+0.250	<.001	4	view →
KIRC	All	All	+0.176	.025	2	view →
ESCA	All	All	+0.640	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMED10–THCA

Open the THCA breakdown →