TMCO1

Across TCGA patient cohorts, TMCO1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO1-associated genes across cancer lineages are Notch1, PCNA, and Rab25. Each is linked with TMCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO1-to-partner and partner-to-TMCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TMCO1-low versus TMCO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO1→partner) and Y-score (partner→TMCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.283	+2.817	<.001	.036	3	1
UCEC	PCNA →	+0.250	+3.169	.035	.020	3	1
UCEC	Rab25 →	-0.466	-3.169	.010	.020	3	1
UCEC	AR →	-0.599	-3.169	.003	.020	3	1
UCEC	BRCA2 →	-0.174	-3.162	.012	.019	3	1
UCEC	Tuberin →	+0.430	+3.169	.003	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Notch1 by TMCO1 expression — UCEC

Explore this box plot interactively →