TMCO1

Across TCGA pan-cancer cohorts, TMCO1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TMCO1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMCO1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMCO1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where TMCO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMCO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.740	<.001	12	view →
KICH	Female	II,III,IV	−1.934	<.001	11	view →
BLCA	All	III,IV	+1.053	<.001	11	view →
THCA	Male	III,IV	−0.972	<.001	10	view →
LIHC	Male	All	+1.499	<.001	9	view →
LUAD	Male	II,III,IV	+0.939	<.001	8	view →
BRCA	All	III,IV	+1.067	<.001	6	view →
STAD	All	All	+0.687	<.001	6	view →
COAD	Female	All	−0.682	<.001	5	view →
KIRC	Female	IV	+0.489	.002	5	view →
LUSC	All	All	+0.548	<.001	4	view →
CHOL	Male	All	+1.866	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TMCO1–HNSC

Open the HNSC breakdown →