TMCC1

Across TCGA patient cohorts, TMCC1 mutation is significantly associated with the RNA expression of many other genes, with 3,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCC1-associated genes across cancer lineages are SSXP9, CRIP1P3, and SFPQP1. Each is linked with TMCC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMCC1-to-partner and partner-to-TMCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSXP9 grouped by TMCC1-low versus TMCC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCC1→partner) and Y-score (partner→TMCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SSXP9 →	+0.275	+4.219	.005	.009	3	3
ACC	CRIP1P3 →	+0.324	+5.228	<.001	.005	3	2
CESC	SFPQP1 →	+0.013	+4.020	<.001	.009	3	2
CESC	IGHD4-4 →	+1.001	+3.424	<.001	.007	3	2
CESC	LINC02559 →	+0.749	+4.020	<.001	.009	3	2
UCEC	ALDOA →	+0.447	+2.687	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,076 associations by consensus.

SSXP9 by TMCC1 expression — STAD

Explore this box plot interactively →