TMC4

Across TCGA cell cohorts, TMC4 mutation is significantly associated with the RNA expression of many other genes, with 491 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMC4-associated genes across cancer lineages are RBMY1D, CTLA4, and YIPF7. Each is linked with TMC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC4-to-partner and partner-to-TMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1D grouped by TMC4-low versus TMC4-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC4→partner) and Y-score (partner→TMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RBMY1D →	+0.026	+5.000	<.001	.005	3	2
OESOPHAGUS	CTLA4 →	+0.027	+2.847	.003	.004	3	2
UPPER_AERODIGESTIVE_TRACT	YIPF7 →	+0.093	+3.722	<.001	.007	3	2
BLOOD_Leukemia	OC90 →	+0.004	+2.979	<.001	.007	3	2
LARGE_INTESTINE	GCAT →	+1.144	+2.502	.002	.005	3	2
LARGE_INTESTINE	FAM149A →	+1.058	+3.067	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 491 associations by consensus.

RBMY1D by TMC4 expression — KIDNEY

Explore this box plot interactively →